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Risk Factors

There are four known risk factors that may predispose a man to develop BPH, commonly reffered to as enlarged prostate:

Aging – is the primary risk factor. While men younger than 40 are rarely affected, approximately half of the men in their 60s experience some symptoms of BPH.
Heredity – a family history of BPH may increase your risk of developing the condition.
Marital status – It is not known why, but men who are married are more likely to develop BPH.
Nationality – BPH is more common in American and European men than in Asian men.

Additionally, there are four theories as to what may cause BPH:

1
BPH does not occur in men who had their testes removed before puberty. It is believed that BPH may be triggered by factors related to the aging of the testes.
2
Healthy males produce testosterone (a male hormone) and a small amount of estrogen (a female hormone). As men age, they naturally produce less testosterone, which changes the balance in the body between the two hormones. Some animal studies suggest that a higher proportion of estrogen may increase the activity of other substances within the body that promote BPH.
3
Males naturally turn testosterone into a chemical called dihydrotestosterone (DHT). Research shows that older men continue to produce large amounts of DHT. DHT which may promote growth of the prostate.
4
Some scientists believe that certain cells in the prostate are programmed to "reawaken" later in life. As these cells begin to multiply and become more active, they may trigger growth in other cells found in the prostate.

Indication
UROXATRAL® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.

Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.

UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure.

Before taking UROXATRAL, tell your doctor if you have kidney problems.

Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.

BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.

The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.

Please see UROXATRAL patient information.